Pre-IND (~2 years, idealized): in silico selection → IND
Audience lens: showing the concept and the “why”, in plain language. Click any stage or gate to read its student view.
Timeline note: The medicinal-chemistry screening cascade dominates; CMC is a supporting lane and GLP toxicology is the late long pole.
Two stacked panels share one 8-quarter timeline. The top panel is a Gantt of development stages grouped into workstream lanes; the bottom panel shows candidate attrition, aligned to the same timeline. Stages and gates are interactive — focus one and press Enter to read its details for the selected audience.
Attrition counts are schematic, order-of-magnitude teaching values — not literal. Real small-molecule libraries span ~10⁴–10⁶; the visible funnel starts lower for legibility.
Timeline caveat: Real preclinical timelines frequently run several years; the 8-quarter window is a compressed teaching frame.
Chemists redesign molecules over many cycles, tweaking structure to improve the whole package, not just potency. It overlaps heavily with testing.